Leah Johansen, M.D., practices alongside Robert Rountree, M.D., at Boulder Wellcare in Boulder, Colorado. Johansen earned her medical degree from Trinity School of Medicine and completed her residency training in family and community medicine at Case Western Reserve University.

If you're a health-conscious individual, then you've probably already heard that taking a little bit of extra magnesium might support your health in a myriad of ways.* Maybe you have a friend who takes magnesium for her headaches or a family member who's an Epsom salt bath enthusiast, or a co-worker who swears by that powdered magnesium she drinks for recovering from post-workout aches.* Whatever the reason, magnesium is one of the most popular supplements in the wellness world.

Why the popularity, you ask? There are a ton of different minerals out there, but few are as involved in our everyday health and wellness as magnesium. For starters, according to the NIH, magnesium plays a key role in more than 300 diverse biochemical reactions in the body. These reactions range from those involved in energy production and protein synthesis to blood sugar control and blood pressure regulation.* In other words: Magnesium is pretty important to our health.

And this brings me to some good news and bad news. The bad news is that it's hypothesized that 50 to 90 percent of us are deficient in this mineral due to factors like medication use, soil depletion, and major pitfalls of the standard American diet (for example: processed foods are virtually devoid of this important mineral).

Magnesium supplements are generally safe and available in many forms—including as traditional supplement capsules, Epsom salts, magnesium oil, magnesium cream, and drinkable powder—that make it easy to incorporate it into your everyday routine. In addition, magnesium is present in some delicious foods like dark leafy green vegetables, legumes and nuts, wheat and other grains, and fish.

Oral magnesium supplements can be found as capsules and powders, and include forms like magnesium citrate, magnesium glycinate, magnesium malate, and magnesium oxide.

Magnesium sulfate can be taken by injection or by IV to treat extreme deficiencies. The dosage for magnesium sulfate is different depending on the type of treatment. Magnesium sulfate can also be used in the form of Epsom salts, which you can add to your bath.

Another popular type of magnesium is transdermal magnesium, which includes magnesium chloride "oils" and creams. But, there is some debate whether or not transdermal magnesium really works, and the science isn't entirely clear. That said, transdermal magnesium cream has demonstrated its effectiveness at increasing blood and urine concentrations of magnesium in a single-blind, parallel study for non-athletes at a dosage of 56 mg/day.

Of all these forms, our experts agree magnesium glycinate is a stand out for a few reasons. Here's what you need to know about it:

Magnesium glycinate is a favorite among integrative and functional medicine doctors and has been researched in quite a few studies. According to Bindiya Gandhi, M.D., an integrative medicine practitioner, "magnesium glycinate has higher bioavailability and is gentle on your stomach, unlike other forms of magnesium."*

Many individuals use magnesium as a sleep aid, and while the mechanism of action isn’t entirely clear, its ability to induce muscle relaxation and ease stress are two of the ways it's thought to help improve sleep.* In a study on the elderly, magnesium glycinate supplementation subjectively improved insomnia.*

Research has shown that magnesium glycinate can help lessen daytime sleepiness and enhance memory.* One study found that taking 125-300 mg of magnesium glycinate daily helped with short-term memory and IQ.*

Magnesium supplementation has a beneficial impact on blood pressure in those who already have a magnesium deficiency.* In fact, one study found that “after magnesium supplementation, systolic and diastolic pressures were significantly [improved].”*

Maintaining a normal blood sugar level is no easy task, but magnesium might be a useful tool in doing so.* Research has shown that dietary magnesium intake (aka, eating foods high in magnesium) reduces the risk of developing type 2 diabetes.* This is because magnesium helps break down sugar, which in turn decreases insulin resistance.*

When it comes to bone health, calcium tends to get most of the attention. But magnesium is involved in bone formation and has an influence on parathyroid hormone and vitamin D concentrations, which are also involved in bone formation.* This means that having an adequate intake of magnesium is useful for supporting healthy bones.*

Low levels of magnesium in the blood (aka, a magnesium deficiency) has been linked to migraine headaches. In addition, supplementing with magnesium has been shown to benefit individuals who have migraines.*

It's true! Studies, like one double-blinded placebo-controlled trial, have shown that taking magnesium glycinate (at a dose of 250 mg per day) helps manage PMS symptoms. You might be surprised by the connection between magnesium and hormones, but according to Jolene Brighten, N.D., a naturopathic doctor, female hormone expert, and founder of Rubus Health, "Magnesium has been shown to be effective in positively helping lower prostaglandins and easing menstrual cramps. Magnesium is also necessary for estrogen detoxification, which is why it can help ease PMS."*

Studies have shown that magnesium glycinate can benefit pregnancy-induced leg cramps.* In one study, 80 pregnant women participated in a double‐blinded, randomized, placebo‐controlled trial by taking 300 mg of magnesium glycinate daily. The frequency of cramping, as well as the intensity of leg cramping, were reduced by 50 percent compared to the placebo group.*

According to experts, supplemental oral magnesium—which includes forms like magnesium citrate, magnesium glycinate, magnesium malate, and magnesium oxide—is safe in the following recommended daily doses:

These dosage recommendations for magnesium can vary slightly, with other sources saying that the recommended daily dose for women should be 320 mg and the recommended dose for men should be 420 mg. Many also suggest that magnesium intake should be increased during pregnancy.

Clearly, there are many benefits to taking magnesium, especially if you have a deficiency in this important mineral.* But are there any downsides to taking magnesium or magnesium glycinate, specifically? The most common side effects of magnesium supplements are diarrhea, cramping, and digestive upset. This is more common in certain forms of magnesium—like magnesium oxide and magnesium citrate.

Maagnesium glycinate is a form of magnesium that has the fewest side effects and doesn't cause digestive upset when taken in a higher dose.* It's thought to be a good choice for individuals with gastrointestinal issues over other magnesium supplements.*

Magnesium citrate is one of the other most commonly recommended sources of magnesium. Magnesium citrate has a laxative effect, but in many cases that's actually a benefit since it's used specifically to treat constipation due to its ability to increase gut motility.* Of all the forms of magnesium, magnesium glycinate is least likely to cause diarrhea, and experts also turn to it for the treatment of a magnesium deficiency due to its high absorbency rate.* According to Dr. Brighten, "Magnesium glycinate is highly absorbable, doesn't cause diarrhea like the citrate form can, and has a calming effect."*

Magnesium citrate and magnesium glycinate are more bioavailable than other common forms of magnesium like magnesium oxide.* They are both great options for magnesium supplementation, depending on your specific needs, whether they be correcting a deficiency and helping with sleep and relaxation (in which case go with the glycinate form), or increasing gut motility and supporting digestion (for these go with the citrate form).*

Hypermagnesemia is the name for a magnesium overdose, which is rare but more common in individuals with kidney disease because the kidneys are responsible for excreting excess magnesium and work to regulate magnesium balance in the body. Overdosing on magnesium can cause serious side effects, including an irregular heartbeat, low blood pressure, confusion, slowed breathing, coma, and even a few deaths have been reported. Keep in mind that an overdose of this measure would require a person to take thousands of milligrams of magnesium daily, which is well beyond the dose in a typical magnesium supplement. 

Although it would be difficult to overdose on magnesium-rich foods or magnesium supplements, magnesium is also the primary ingredient in some prescription and over-the-counter laxatives, and severe hypermagnesemia has been reported to occur from taking laxatives that contain magnesium for constipation over a long-term period. Fatal hypermagnesemia can occur in those with renal problems when taking these laxatives because kidneys that are not fully functional are not able to effectively clear magnesium from the body. As a general rule, you should always talk to your doctor before taking a new supplement.

Magnesium can also interact with certain medications, for example, with certain types of antibiotics. It is usually recommended to take antibiotics at least 2 hours before or 4 to 6 hours after a magnesium-containing supplements. Another group of drugs that magnesium tends to interact with is bisphosphonates that are often used to treat osteoporosis. Magnesium can interfere with how well this drug is absorbed, so the supplement should be taken at least two hours before or after these medications."

56-40-6 Glycine Price

Bottom line: Magnesium glycinate is one of the most absorbable forms of magnesium. For this reason, it is a great option if you are looking to reap the benefits of magnesium supplementation, like sleep support, enhanced memory, and PMS relief.*

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